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Overall focus

The laboratory focuses on the study of how brain pathologies affect the neurovascular unit and how these changes lead to the disruption of the Blood-Brain Barrier (BBB).  Overall, it is our hope that the studies pursued will lead to the discovery of therapeutic agents that are both anti-inflammatory and barrier protective in order to attenuate the deleterious outcomes of neuroinflammation and neurodegeneration.  In addition to endothelial/vascular biology, our expertise also includes neuroscience, immunology, molecular biology, microbiology, biochemistry and microfluidics.  Importantly, (in addition to in-vitro and ex-vivo methodologies) the laboratory also routinely utilizes animal models to study disease progression and for testing novel therapeutic approaches.  In particular, as it relates to drug abuse, sepsis, HIV-1 related CNS inflammation and traumatic brain injury.  Lastly, we employ a translational approach to our research by using primary human cells and relevant clinical samples (i.e., tissue, serum, CSF) to validate and further extend our findings.

Human neural stem cells express tight junction proteins to enhance cell-to-cell attachment 

Microglial cells at various stages of activation 

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